翻訳と辞書 Words near each other ・ Asparrena ・ Aspartame ・ Aspartame controversy ・ Aspartame-acesulfame salt ・ Aspartate 1-decarboxylase ・ Aspartate 4-decarboxylase ・ Aspartate ammonia-lyase ・ Aspartate carbamoyltransferase ・ Aspartate dehydrogenase ・ Aspartate kinase ・ Aspartate N-acetyltransferase ・ Aspartate protease ・ Aspartate racemase ・ Aspartate receptor ・ Aspartate transaminase ・ Aspartate-semialdehyde dehydrogenase ・ Aspartate—ammonia ligase ・ Aspartate—ammonia ligase (ADP-forming) ・ Aspartate—phenylpyruvate transaminase ・ Aspartate—prephenate aminotransferase ・ Aspartate—tRNA ligase ・ Aspartate—tRNA(Asn) ligase ・ Aspartic acid ・ Aspartic acid (data page) ・ Aspartic alpha-decarboxylase ・ Aspartoacylase ・ Aspartyl aminopeptidase ・ Aspartylglucosamine ・ Aspartylglucosaminidase ・ Aspartylglucosaminuria Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Aspartate-semialdehyde dehydrogenase ： ウィキペディア英語版 Aspartate-semialdehyde dehydrogenase In enzymology, an aspartate-semialdehyde dehydrogenase () is an enzyme that is very important in the biosynthesis of amino acids in prokaryotes, fungi, and some higher plants. It forms an early branch point in the metabolic pathway forming lysine, methionine, leucine and isoleucine from aspartate. This pathway also produces diaminopimelate which plays an essential role in bacterial cell wall formation. There is particular interest in ASADH as disabling this enzyme proves fatal to the organism giving rise to the possibility of a new class of antibiotics, fungicides, and herbicides aimed at inhibiting it. The enzyme catalyzes the reversible chemical reaction :L-aspartate 4-semialdehyde + phosphate + NADP+ $\backslash rightleftharpoons$ L-4-aspartyl phosphate + NADPH + H+ The 3 substrates of this enzyme are L-aspartate 4-semialdehyde, phosphate, and NADP+, whereas its 3 products are L-4-aspartyl phosphate, NADPH, and H+. In physiological conditions however, the reaction runs in the opposite direction. This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating). Other names in common use include aspartate semialdehyde dehydrogenase, aspartic semialdehyde dehydrogenase, L-aspartate-beta-semialdehyde:NADP+ oxidoreductase, (phosphorylating), aspartic beta-semialdehyde dehydrogenase, and ASA dehydrogenase. This enzyme participates in glycine, serine and threonine metabolism and lysine biosynthesis. Aspartate-semialdehyde dehydrogenase may be cis-regulated by an Asd RNA motif found in the 5' UTR of some Asd genes. == Protein families == This domain contains both N-acetyl-glutamine semialdehyde dehydrogenase (AgrC), which is involved in arginine biosynthesis, and aspartate-semialdehyde dehydrogenase, an enzyme involved in the biosynthesis of various amino acids from aspartate. It also contains the yeast and fungal Arg5,6 protein, which is cleaved into the enzymes N-acetyl-gamma-glutamyl-phosphate reductase and acetylglutamate kinase. These are also involved in arginine biosynthesis. All proteins in this entry contain a dimerisation domain of semialdehyde dehydrogenase. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Aspartate-semialdehyde dehydrogenase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.